&lt;p&gt;HIV Treatment&amp;nbsp;&lt;span style=&quot;color: #ff0000;&quot;&gt;|&lt;/span&gt; New Medication&lt;/p&gt;
&lt;h1&gt;KOCITAF (Dolutegravir, Emtricitabine, Tenofovir Alafenamide) as HIV treatment&lt;/h1&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p style=&quot;-qt-block-indent: 0; text-indent: 0px; margin: 0px;&quot;&gt;&lt;strong&gt;Order Kocitaf - Dolutegravir, Emtricitabine &amp;amp; Tenofovir Alafenamide HIV Treatment Medication Online Now. Please&amp;nbsp;&lt;/strong&gt;&lt;strong&gt;email us at&amp;nbsp;&lt;a href=&quot;mailto:info.silom@pulse-clinic.com&quot;&gt;info.bkk@pulse-clinic.com&lt;/a&gt;&amp;nbsp;or have a chat with us on your preferred platform&amp;nbsp;&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;-qt-block-indent: 0; text-indent: 0px; margin: 0px;&quot;&gt;&amp;nbsp;&lt;/p&gt;
&lt;p style=&quot;-qt-block-indent: 0; text-indent: 0px; margin: 0px;&quot;&gt;&lt;strong&gt;&amp;nbsp;&lt;a href=&quot;https://wa.me/66842262569&quot;&gt;&lt;img src=&quot;https://cms.pulse-clinic.com/Files/WhatsApp.png&quot; width=&quot;48&quot; height=&quot;82&quot; /&gt; &lt;span class=&quot;w-30 inline-block px-2 md:px-4 mt-3&quot;&gt; +66-84-226-2569&amp;nbsp;&lt;/span&gt;&lt;/a&gt;&lt;a href=&quot;https://line.me/ti/p/~@442yeswp&quot;&gt;&lt;img src=&quot;https://cms.pulse-clinic.com/Files/line-logo.png&quot; width=&quot;50&quot; height=&quot;85&quot; /&gt; &lt;span class=&quot;w-30 inline-block px-2 mt-3&quot;&gt; @442yeswp&amp;nbsp;&lt;/span&gt;&lt;/a&gt;&lt;a href=&quot;weixin://dl/chat?pulseclinic&quot;&gt; &lt;img src=&quot;https://cms.pulse-clinic.com/Files/WeChat_App_Icon.png&quot; width=&quot;50&quot; height=&quot;85&quot; /&gt; &lt;span class=&quot;w-30 inline-block px-2 mt-3&quot;&gt; PulseClinic&lt;/span&gt;&lt;/a&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;-qt-block-indent: 0; text-indent: 0px; margin: 0px;&quot;&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;&amp;nbsp;&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;h2&gt;&lt;strong&gt;A new anti-HIV drug has arrived in Singapore.&lt;/strong&gt;&lt;/h2&gt;
&lt;p&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;The combination anti-HIV drug Kocitaf was now approved by the Food and Drug Administration of Thailand on February 3, 2021, and is intended for the treatment of adults and adolescents (aged 12 years and over and has It is hoped that the government will soon allow people living with HIV to receive the drug with gold patents and social security. What are the advantages and disadvantages of this drug compared to the current popular formulation (Teevir brand)? First of all, I would like to present a fairly academic content so that the reader can gain a rather in-depth knowledge of the drug.&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;Kocitaf contains&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;Tenofovir alafenamide fumarate (TAF) 25 mg&lt;/span&gt;&lt;/li&gt;
&lt;li&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;Emtricitabine (FTC) 200 mg&lt;/span&gt;&lt;/li&gt;
&lt;li&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;Dolutegravir (DTG) 50 mg&lt;/span&gt;&lt;/li&gt;
&lt;/ul&gt;
&lt;h2&gt;&lt;strong&gt;Introduction to the division process of the HIV virus&lt;/strong&gt;&lt;/h2&gt;
&lt;p&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;antiretroviral drugs used to treat people with HIV Multiple combinations are required. This is because the HIV virus is complex in the process of reproduction. HIV is a retro virus, observed by its genetic transcription process, from the underlying RNA to DNA, which appears to be a reverse process. It relies on the resources of white blood cells to regenerate itself, which consists of several steps. both within the nucleus and other elements of the cell Therefore, a single drug is not enough to inhibit the replication of the virus. The rough process of virus propagation is as follows (1) (shown in Figure 1).&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;Attaches to the cell wall and enters the cell (Virus entry)&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;Transcription RNA to make viral DNA (Reverse Transcription)&lt;/span&gt;&lt;/li&gt;
&lt;li&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;into the nucleus, its DNA is inserted into the DNA of the cell (Integration)&lt;/span&gt;&lt;/li&gt;
&lt;li&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;DNA strands are removed as mRNA and Genomic RNA and leave the nucleus. (Transcription)&lt;/span&gt;&lt;/li&gt;
&lt;li&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;Viral mRNA is decoded to synthesize proteins to make up new viral components. (Translation)&lt;/span&gt;&lt;/li&gt;
&lt;li&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;The protein strands are cut into tiny particles to prepare for cleavage. (Cleavage)&lt;/span&gt;&lt;/li&gt;
&lt;li&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;Genomic RNA and synthesized proteins make up several new viruses (Assembly)&lt;/span&gt;&lt;/li&gt;
&lt;li&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;The new virus prepares to leave the cell wall intact (Budding and Maturation)&lt;/span&gt;&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;&lt;img src=&quot;https://cms.pulse-clinic.com/Files/HIV%20MEDS/reproductive-cycle-hiv-1-sites-action-major-classes-antiretroviral-medications-kocitaf%20for%20pep.jpg&quot; width=&quot;900&quot; height=&quot;783&quot; /&gt;&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;Source: Gandhi M, Gandhi RT. Single-pill combination regimens for treatment of HIV-1 infection. N Engl J Med. 2014;371:248-59.&lt;br /&gt;&amp;copy; 2014 Massachusetts Medical Society. Figure and Legend Reproduced with permission.&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;

&lt;h2&gt;&lt;strong&gt;A new drug of choice for emergency PEP and treating people with HIV&lt;/strong&gt;&lt;/h2&gt;
&lt;p&gt;&lt;strong&gt;Kocitaf&lt;/strong&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt; contains two non-nucleoside reverse transcriptase inhibitors (NNRTIs), &lt;/span&gt;&lt;strong&gt;TAF&lt;/strong&gt; &lt;span style=&quot;color: #99ccff;&quot;&gt;and emtricitabine. Combined with one Integrase strand transfer inhibitors (INSTIs), &lt;/span&gt;&lt;strong&gt;Dolutegravir&lt;/strong&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;.&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;by TAF and Emtricitabine It inhibits HIV viral replication in Process 2 (Reverse transcription) and Dolutegravir inhibits Process 3 (Integration).&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;The 2017 Thailand HIV Treatment and Prevention Guidelines state that TDF is the basic antiretroviral drug. It is most commonly used as a first-line treatment. (2) In general, for treatment, TDF is usually taken as one tablet (300 mg) once a day in combination with other antiretrovirals. However, this dosage was quite high. which the drug recipient must take every day continuously Therefore, they are more likely to experience side effects from the use of this drug, such as nephrotoxicity and bone marrow, which requires regular monitoring of kidney function.&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Tenofovir Alafenamide fumarate (TAF)&lt;/strong&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt; is a new drug that is gaining attention. It can help reduce side effects on kidneys and bones by using doses much lower than TDF.&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Dolutegravir (DTG)&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;It is a second-generation integrative inhibitors and was approved by the U.S. Food and Drug Administration (FDA) in 2013 for its high resistance to HIV virus. Tivicay 10, 25, and 50 mg single tablets are available, and Triumeq combined tablets contain Abacavir 600mg, Lamivudine 300mg, Dolutegravir 50mg.&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;The pharmacokinetics of Dolutegravir is more than 98.9% bound to blood proteins. Its volume of distribution is 17.4 L. The plasma half-life is 14 hours. The drug is metabolized via UGT1A1 and partially via the CYP3A enzyme. It affects CYP3A. When used with dolutegravir, it also affects the level of dolutegravir in the body. For example, antacids or multiionic drugs can decrease dolutegravir levels. The drug is eliminated in the stool by 53%.&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;It was found that the food taken with this drug increase the amount of drug absorption but reduces the rate of drug absorption But it is not clinically insignificant. Therefore, this drug may or may not be taken with food.&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;Interactions between dolutegravir and metformin (for diabetes) were found to increase Metformin levels 2.4-fold and peak Metformin 2-fold.&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;Dolutegravir plus Rifampicin (tuberculosis treatment) has been found to decrease dolutegravir by 54%. Therefore, dolutegravir 50 mg originally taken once a day may need to be increased to twice a day.&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;Dolutegravir side effects such as insomnia, headache, and depression can occur in patients with a history of psychiatric problems. Pregnant women should be careful Especially at less than 8 weeks of gestation, if you have not started antiretroviral therapy. It is advisable to start with another antibody formulation instead. If you are over 8 weeks pregnant, you can receive Dolutegravir under close monitoring by your doctor.&lt;/span&gt;&lt;/p&gt;
&lt;h2&gt;&amp;nbsp;&lt;/h2&gt;
&lt;h2&gt;&lt;strong&gt;New recommendation from WHO&lt;/strong&gt;&lt;/h2&gt;
&lt;p&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;The World Health Organization has released an Update of recommendations on first- and second-line antiretroviral regimens Policy brief 22 July 2019, recommending Dolutegravir over Efavirenz due to less drug&amp;ndash;drug interactions, faster viral suppression, higher genetic barrier to drug resistance Although dolutegravir may cause weight gain, the issue of neural tube defects in infants in Botswana is unclear. and from the study compare with efavirenz-based No differences were found, including the incidence in other countries did not increase.&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;KOCITAF is available foremergency HIV prevention (Post-exposure prophylaxis) and for HIV treatment at PULSE CLINIC throughout Thailand.&lt;/span&gt;&lt;/p&gt;

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