&lt;h1 class=&quot;heading-title&quot;&gt;&lt;a title=&quot;Frequent ejaculation associated free radical and lactic acid accumulation cause noninfectious inflammation and muscle dysfunction: a potential mechanism for symptoms in Chronic Prostatitis/Chronic Pelvic Pain Syndrome&quot; href=&quot;https://pubmed.ncbi.nlm.nih.gov/19435656/&quot;&gt;Frequent ejaculation associated free radical and lactic acid accumulation cause noninfectious inflammation and muscle dysfunction: a potential mechanism for symptoms in Chronic Prostatitis/Chronic Pelvic Pain Syndrome&lt;/a&gt;&lt;/h1&gt;
&lt;p&gt;&lt;span style=&quot;color: #99ccff;&quot;&gt;During male ejaculation, the pelvic muscles undergo coordinated intense contraction to expel the semen out of the male genital tract, a process associated with locally increased levels of lactic acid and free radicals as byproducts. In this regards, repetitive sexual activities with frequent ejaculation would impede the drainage and cause accumulation of these byproducts in the pelvic region, triggering consequent local pathophysiological changes such as edema, venous dilation and muscular malfunction, which further leads to common complaints in Chronic Prostatitis (CP)/Chronic Pelvic Pain Syndromes (CPPS). patients such as lower urinary tract symptoms, pelvic discomfort and pain.&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;hr /&gt;
&lt;div class=&quot;article-content-section&quot;&gt;
&lt;h3 id=&quot;references&quot; class=&quot;reg&quot;&gt;References&lt;/h3&gt;
&lt;ol class=&quot;references&quot;&gt;
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&lt;li&gt;Comarr AE:&amp;nbsp;&lt;a href=&quot;http://www.ncbi.nlm.nih.gov/pubmed/5422714&quot; target=&quot;_blank&quot; rel=&quot;noopener&quot;&gt;Sexual function among patients with spinal cord injury&lt;/a&gt;. Urol Int. 1970, 6:134-68.&lt;/li&gt;
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&lt;li&gt;Blanker MH, Bosch JL, Groeneveld FP:&amp;nbsp;&lt;a href=&quot;http://www.ncbi.nlm.nih.gov/pubmed/11306400&quot; target=&quot;_blank&quot; rel=&quot;noopener&quot;&gt;Erectile and ejaculatory dysfunction in a community-based sample of men 50 to 78 years old: prevalence, concern, and relation to sexual activity&lt;/a&gt;. Urology. 2001, 57:763-8.&lt;/li&gt;
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&lt;li&gt;Barnas JL, Pierpaoli S, Ladd P:&amp;nbsp;&lt;a href=&quot;https://dx.doi.org/10.1111/j.1464-410X.2004.05009.x&quot; target=&quot;_blank&quot; rel=&quot;noopener&quot;&gt;The prevalence and nature of orgasmic dysfunction after radical prostatectomy&lt;/a&gt;. BJU Int. 2004, 94:603-5.&amp;nbsp;&lt;span class=&quot;citation-doi&quot;&gt;&lt;a href=&quot;https://dx.doi.org/10.1111/j.1464-410X.2004.05009.x&quot; target=&quot;_blank&quot; rel=&quot;noopener&quot;&gt;10.1111/j.1464-410X.2004.05009.x&lt;/a&gt;&lt;/span&gt;&lt;/li&gt;
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&lt;li&gt;Sundar R, Sundar G:&amp;nbsp;&lt;a href=&quot;https://dx.doi.org/10.1136/bcr-2014-207618&quot; target=&quot;_blank&quot; rel=&quot;noopener&quot;&gt;Zinner syndrome: an uncommon cause of painful ejaculation&lt;/a&gt;. BMJ Case Rep. 2015, 2015:1-5.&amp;nbsp;&lt;span class=&quot;citation-doi&quot;&gt;&lt;a href=&quot;https://dx.doi.org/10.1136/bcr-2014-207618&quot; target=&quot;_blank&quot; rel=&quot;noopener&quot;&gt;10.1136/bcr-2014-207618&lt;/a&gt;&lt;/span&gt;&lt;/li&gt;
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&lt;li&gt;Wang H, Ye H, Xu C:&amp;nbsp;&lt;a href=&quot;https://dx.doi.org/10.2164/jandrol.111.013912&quot; target=&quot;_blank&quot; rel=&quot;noopener&quot;&gt;Transurethral seminal vesiculoscopy using a 6F vesiculoscope for ejaculatory duct obstruction: initial experience&lt;/a&gt;. J Androl. 201, 33:637-43.&amp;nbsp;&lt;span class=&quot;citation-doi&quot;&gt;&lt;a href=&quot;https://dx.doi.org/10.2164/jandrol.111.013912&quot; target=&quot;_blank&quot; rel=&quot;noopener&quot;&gt;10.2164/jandrol.111.013912&lt;/a&gt;&lt;/span&gt;&lt;/li&gt;
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&lt;li&gt;Barnas J, Parker M, Guhring P, Mulhall JP:&amp;nbsp;&lt;a href=&quot;https://dx.doi.org/10.1016/j.eururo.2004.10.020&quot; target=&quot;_blank&quot; rel=&quot;noopener&quot;&gt;The utility of tamsulosin in the management of orgasm-associated pain: a pilot analysis&lt;/a&gt;. Eur Urol. 2005, 47:361-5.&amp;nbsp;&lt;span class=&quot;citation-doi&quot;&gt;&lt;a href=&quot;https://dx.doi.org/10.1016/j.eururo.2004.10.020&quot; target=&quot;_blank&quot; rel=&quot;noopener&quot;&gt;10.1016/j.eururo.2004.10.020&lt;/a&gt;&lt;/span&gt;&lt;/li&gt;
&lt;li&gt;Jordi PM, Maria-Jos&amp;eacute; AM, Luis-Alfonso MM, Mauro SM:&amp;nbsp;&lt;a href=&quot;https://journals.lww.com/clinicalpain/Abstract/2004/09000/Management_of_Ejaculation_Pain_With_Topiramate__A.14.aspx&quot; target=&quot;_blank&quot; rel=&quot;noopener&quot;&gt;Management of ejaculation pain with topiramate: a case report&lt;/a&gt;. Clin J Pain. 2004, 20:368-369.&lt;/li&gt;
&lt;/ol&gt;
&lt;/div&gt;

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